Hansi Flick’s side has struggled when the 17-year-old is not on the pitch, as the Spain international has become a crucial part of their attacking gameplan.
With Yamal set to miss the trip to Galicia because of an ankle problem, the German coach needs a plan B.
The teenager was rested for Barcelona’s visit to face Osasuna in September, with the Catalans losing 4-2.
Appearing as a substitute with Barcelona trailing, Yamal scored a superb late goal to remind Flick of his importance to the team.
Since then, he started every match for Barcelona until injury kept him out of the team that lost 1-0 at Real Sociedad before the international break.
Flick put Raphinha on the left wing and used Fermin Lopez out of position on the right and his team failed to create many chances in San Sebastian, despite having scored 40 goals in the 12 league games preceding.
“Of course, a player with the quality Lamine has, every team (would) miss it,” admitted Flick after the defeat. “In the last third, we weren’t making the right decisions.”
With Dani Olmo seemingly fit again after injury, the playmaker can add more quality in the final third for Barcelona and supply striker Robert Lewandowski with the ammunition he needs to thrive.
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The veteran Polish forward is the league’s top goalscorer with 14 strikes but also failed to find the net in the games where Yamal did not start.
With the youngster’s skill and speed attracting opposition defenders and his creativity crucial in teeing up Lewandowski, their connection has been vital to Barcelona’s campaign.
Lamine Yamal is also a fine foil for Raphinha when Barcelona counter-attacks at pace, with the Brazilian winger, in the form of his career, often racing onto clever passes played by the Spaniard to devastating effect.
With Ferran Torres also out injured, Flick could turn to winger Pau Victor to replace Yamal or use Pablo Torre in attacking midfield with Olmo shifted to the left wing and Raphinha on the right.
Claudio Giraldez’s Celta Vigo, 11th, boasts former Barcelona defender Marcos Alonso in their ranks.
“It’s special because we play against the leaders,” said Alonso. “We have shown in previous games against big sides we can compete, but we haven’t managed to get a good result.”
Celta Vigo came close to upsetting Real Madrid but were beaten 2-1 by the Spanish champions in October.
Barcelona have only won twice in their last nine visits to Balaidos. A win for Barcelona could take them nine points clear of Madrid before they visit Leganes on Sunday.
Elsewhere, Atletico Madrid, third, hosts Alaves, while Valencia host Real Betis in their first match since devastating floods hit the region causing loss of life and severe damage on the east coast.
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