The tourists hit their joint third-highest total in women’s T20 internationals in Benoni, setting the Proteas a target of 205.
Danni Wyatt-Hodge hit 78 from 45 becoming the first England Women’s player to score 3000 T20I runs while Nat Sciver-Brunt finished unbeaten on 67 from 43 balls. Player of the match Sarah Glenn took four wickets.
Captain Heather Knight and Amy Jones both contributed with 26 and 19 respectively.
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Sciver-Brunt took the early wicket of Tazmin Brits and Charlie Dean dismissed South Africa captain Laura Wolvaardt.
Glenn removed Faye Tunnicliffe, Annerie Dercksen, Nondumiso Shangase, and Chloe Tryon to seal her side’s victory.
England and South Africa will play the final T20I at SuperSport Park, Centurion on Saturday (30 November).
South Africa Women Playing XI: Laura Wolvaardt (capt), Tazmin Brits, Faye Tunnicliffe, Annerie Dercksen, Chloe Tryon, Nondumiso Shangase, Nadine de Klerk, Sinolo Jafta (wk), Eliz-Mari Marx, Nonkululeko Mlaba, Ayanda Hlubi
England Women Playing XI: Danni Wyatt-Hodge, Maia Bouchier, Sophia Dunkley, Nat Sciver-Brunt, Heather Knight (capt), Amy Jones (wk), Freya Kemp, Sophie Ecclestone, Charlie Dean, Sarah Glenn, Lauren Filer
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