In their first PSL 9 match away from home, Multan Sultans opted to bat first but Lahore Qalandars drew first blood with captain Shaheen Afridi castling opposing captain Mohammad Rizwan in the first over.
But the Sultans made a comeback quickly with a brilliant 70-run partnership between Reeza Hendricks and Usman Khan before Sikandar Raza struck to dismiss the former.
Hendricks scored a 27-ball 40 with the help of seven boundaries including one six.
Khan continued his onslaught and was involved in a one-sided partnership with Tayyab Tahir, raising 77 runs in only 40 balls for the third wicket.
Tahir scored only 21 runs and was sent to the pavilion by Carlos Brathwaite with a scoreboard reading 151 in 15 overs.
Iftikhar Ahmed joined Khan and wreaked havoc with a blistering unbeaten cameo of 40 runs from 18 balls, which featured two boundaries and three sixes.
Khan on the other hand scored 96 runs from 55 balls, laced with 13 boundaries, including two sixes but missed his hundred as he got out in the final over.
Multan Sultans finished their innings at 214-4 in their allocated 20 overs.
For Lahore Qalandars, Afridi led the bowling with the figures of 2-39, while Raza and Brathwaite claimed one wicket each.